During an operation on the banks of the Elbe in Dresden, paramedic Tarik Wasir was suffocated with a plastic bag in the vehicle. His young colleague Greta Blaschke can no longer help him. The investigators Karin Gorniak and Leonie Winkler as well as Commissariat Manager Schnabel investigate in all directions. The rampaging patient Arnold Liebig, whose health insurance has cut benefits, is just as suspicious as Greta's colleague Hagen Rigmers, who seems to be hiding something and threatens his colleagues. A short time later, a second attack is carried out on an ambulance at the same location. Paramedic Elena Jancowicz is seriously injured, and any help comes too late for a colleague. At the rescue station headed by Peter Fritsche, the fear of further attacks increases.

Greta Blaschke is at the end of her strength because of the murder of her colleague and her strenuous job. The single mother hopes to distract herself from an evening date with Jens Schlueter, whom she met in her daughter's kindergarten. Little does she know that along the way she will be confronted with a traumatic experience from her past and that she is putting herself in extreme danger.